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Previews Skirball Institute of Biomolecular Medicine New York Saturn Med Nyu  Form

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Hello. I'm Michael Dustin from the University of Oxford and New York University School of Medicine. Today, I'm going to talk to you about the immunological synapse, Part 1 - antigen recognition. So, I'll follow this outline. I'll start with a general discussion of immune systems and their basic purpose; and the idea that there's innate immunity, which recognizes evolutionarily conserved patterns and sets up barriers to protect the host, and adaptive immunity, which can recognize any type of threat without any kind of prior experience of it, and how these systems work together; the physical challenges of antigen recognition for T-lymphocytes, which I'll introduce in a moment; and adhesion molecules that meet some of these challenges; and how these are coordinated in an immunological synapse. So, immunity is critical for essentially all forms of life. Once you start concentrating a lot of energy in a small package, there are always going to be other organisms, typically smaller, microbes

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