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Research and Development R&DOverview & Process Form

Research and Development R&DOverview & Process Form

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In order to understand what Global Clinical Connections does and how we are involved, I think it is first important to understand the research and development process, in other words, R&D. Let's start with the research side of things. It all begins in the lab. In research laboratories, thousands of compounds are tested in cells, tissues, and small mammals. They are usually a couple milligrams or micrograms of material tested in a high throughput screen. This is done to identify which drugs have activity and which drugs do not have activity. From these materials, out of maybe ten thousand drugs, there may be 30 drugs which are active. From the thirty drugs, there is another round of screening with medium sized mammals like dogs or cats where we can narrow down the drug activity. Narrowing down from maybe thirty to five, we can look at larger animals such as monkeys, cows, pigs - which are models to mimic man's physiology - and so to see which ones are the continu

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