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Substitution Vs Elimination Chart  Form

Substitution Vs Elimination Chart Form

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- [Instructor] When you're trying to determine between a substitution and an elimination reaction, it's important to consider the function of the reagent. Does your reagent function as a nucleophile or does it function as a base? So first let's look at nucleophile. Let's consider the idea of charge. We know that water can function as a nucleophile so we have a region of high electron density around the oxygen. The oxygen is partially negative because oxygen is more electrode negative than hydrogen so these hydrogens are partially positive. So water can function as a nucleophile, however it is a weak nucleophile because we do not have as high a region of electron density as we would with the hydroxide ion. So the hydroxide ion is a strong nucleophile. It has a full negative charge on the oxygen instead of only a partial negative charge. Next let's consider the polarizability of the nucleophile. Let's compare the hydroxide ion with hydrogen sulfate. So we've already seen the hydroxide io

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