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Drchrismolen Io Form

Drchrismolen Io Form

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[Music] so moving forward uh with these symptomatic patients how do I choose the Frontline Therapies so just as a brief timeline um you know we are in a golden age for Therapies in myofibrosis and MPN I mentioned the activation of the Jack stat pathway as kind of an analogy of a light switch and we have all these therapies collectively known as Jack Inhibitors that that can turn off this light switch there are four main Jack Inhibitors nowadays that are approved in the past decade or so mainly ruxolitinib fedratinib pit nib and molot nib that can do exactly that now how they work they inhibit a couple different receptors on the patient's uh Mal malignant cells that are really important including Jack one Jack 2 and acvr1 Jack 1 and Jack 2 as they're signaled um Downstream into the DNA they use the Jack stat pathway that I mentioned is the most important part of mpns but for myo prolifer of neoplasms inhibiting this one on the right side the Jack 2 is the most important

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