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PDF HEPATIC PATHOLOGY Additional Information Request Form

PDF HEPATIC PATHOLOGY Additional Information Request Form

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Alright, so when you drink alcohol, what happens? Well, okay, what happens to the alcohol? Well that’s mainly your liver’s job, right? Basically, once the alcohol gets to your stomach, most of it’s sent to your liver for processing. In very small amounts, alcohol is more or less harmless, but in excess, it can lead to serious liver complications, and is the leading cause of liver disease in western nations. Once in the liver cells or hepatocytes, it can take one of three pathways, one of which involves an enzyme called alcohol dehydrogenase or simply ADH, and this happens in the cytosol of the cell, another involves a catalase inside organelles called peroxisomes, and a third involves being converted by the enzyme cytochrome P450 2E1, sometimes just shortened to CYP2E1. All three of these pathways lead to the conversion of alcohol to acetaldehyde. Once the ADH enzyme is used to convert the alcohol, it needs another compound called NAD+, which is then converted into NADH. As NADH

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