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Functional Heterogeneity of CD11c Positive Adipose Tissue Jbc Form
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People also ask
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What is adipogenic differentiation?
Adipogenesis is the process of cell differentiation during which fibroblast-like preadipocytes develop into mature adipocytes. The process is one of the most intensively studied models of cellular differentiation, often using 3T3-L1 preadipocytes as models for study. -
What is the leptin signal in adipose tissue?
Leptin produced by the adipose tissue acts as an afferent signal in a negative feedback loop in the homeostatic control of adipose tissue mass, regulating food intake and energy expenditure [3]. -
What is the meaning of adipogenic?
Adipogenesis is the process by which fat-laden cells, that is, adipocytes, develop and accumulate as adipose tissue at various sites in the body, both as subcutaneous fat and as depots. -
Why does leptin increase lipolysis?
Unger's laboratory study at the University of Texas Southwestern at Dallas has previously reported that leptin can deplete fat mass through several mechanisms such as via PPARα and its target genes of fatty acid (FA) oxidation9); hence, one can assume that leptin stimulates lipolysis by activating adipocyte lipase(s) ... -
What is the adipogenic differentiation cocktail?
The adipogenic cocktail is the most utilized differentiation medium (DM) for 3T3-L1 cells differentiation, but the concentrations of the three major inducers (DEX, IBMX, and ) vary from study to study. Many researchers have established improved methods to obtain higher differentiation efficiency. -
What signal molecules are secreted by adipose tissue?
Adipocytes and adipose tissue associated macrophages (ATMs) secrete bioactive molecules, including adipokines, chemokines/cytokines and free fatty acids that modulate the development of low-grade inflammation and resistance responsible for obesity-related metabolic and cardiovascular diseases. -
What is the effect of leptin on Lipogenesis?
Leptin is an adipokine released from white adipose tissue in proportion to the size of fat depots. Leptin inhibits food intake, increases energy expenditure and reduces body fat. Leptin reduces fat pad size by inhibiting lipogenesis and increasing lipolysis. -
What are leptin signals?
Leptin has a more profound effect when you lose weight. As your body fat (adipose tissue) decreases, your leptin levels decrease, which signals your body to think that it's starving. This stimulates intense hunger and appetite and can lead to increased food consumption. -
What is adipose tissue differentiation?
Adipocyte differentiation is characterized by sequential changes in the expression of specific genes that determine the specific adipocyte phenotype of the cells. This is reflected by the appearance of various early, intermediate and late mRNA/protein markers and triglyceride accumulation. -
Is leptin an adiposity signal?
Leptin and fulfill many of the requirements to be putative adiposity signals to the brain. Plasma leptin and levels are positively correlated with body weight and with adipose mass in particular. -
What does leptin do to adipose tissue?
Leptin is an adipokine released from white adipose tissue in proportion to the size of fat depots. Leptin inhibits food intake, increases energy expenditure and reduces body fat. Leptin reduces fat pad size by inhibiting lipogenesis and increasing lipolysis.
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