
Functional Heterogeneity of CD11c Positive Adipose Tissue Jbc Form
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People also ask
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What is CD11c expression in macrophages?
CD11c macrophages express the protein CD11c. They are involved in numerous immune responses, including combating infection and cancer. They have a variable level of CD11c expression, which can be a powerful tool in identifying subsets within the immune system.
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What is the composition of white adipose tissue?
White adipose tissue White fat cells (adipocytes) have a simple structure composed of a single lipid droplet (fat molecule) and a few cellular organelles. They provide energy storage, insulation from extreme temperatures and cushioning around soft organs.
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Is CD11c an M1 marker?
Flow cytometry. F4/80 was used as a pan-macrophage marker, and CD11c was used as an M1 macrophage marker. To detect the cell-surface expression of CD11c, Raw 264.7 cells were cultured with BSA, AGEs or LPS for 24 h.
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What are the markers for M1 macrophages?
iNOS expression is a well-known marker of M1 macrophages. CD68: CD68 is a transmembrane glycoprotein primarily expressed on the surface of macrophages and monocytes. It is also found in other cells, including microglia, Kupffer cells, and dendritic cells.
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What is CD11c a marker of?
CD11c is a widely established marker for dendritic cells (see CD11c protein and function). It can be employed to determine the subsets of dendritic cells (DC) in the immune system (see CD11c expression in human and murine immune system), but CD11c may be more than a marker for DC cells (see CD11c and inflammation).
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Is CD11c M1 or M2?
In a study published in Nature, it was discovered that CD11c+ M1-like macrophages, but not CD206+ M2-like macrophages, are involved in folliculogenesis in mice ovary. This highlights the unique roles of different macrophage subsets and the correlation with the CD11c marker.
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What disease affects adipose tissue?
Lipodystrophy. Lipodystrophy is a condition that's characterized by a complete or partial loss of and/or abnormal distribution of adipose (fat) tissue in certain areas of your body. While there's no cure for the condition, certain treatments can help with its symptoms and associated health conditions.
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