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Partial Gene Deletion of Heart Type Fatty Acid Binding Protein Diabetes Diabetesjournals Form
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People also ask
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What is the function of the FABP1?
FABP1 is known to be critical for fatty acid uptake and intracellular transport and also has an important role in regulating lipid metabolism and cellular signaling pathways. -
What does fatty acid binding protein do?
Fatty acid-binding proteins (FABPs) are members of the intracellular lipid-binding protein (iLBP) family and are involved in reversibly binding intracellular hydrophobic ligands and trafficking them throughout cellular compartments, including the peroxisomes, mitochondria, endoplasmic reticulum and nucleus. -
What is the function of the heart type fatty acid binding protein?
Under physiological conditions, H-FABP serves as a transport protein in cellular metabolism and can reversibly bind fatty acids. Furthermore, it can activate PPARs and therefore plays a role in lipid metabolism and energy homeostasis. -
What is the heart-type fatty acid binding protein test?
H-FABP is recommended to be measured with troponin to identify myocardial infarction and acute coronary syndrome in patients presenting with chest pain. H-FABP measured with troponin shows increased sensitivity of 20.6% over troponin at 3–6 hours following chest pain onset. -
What is the function of FABP3?
FABP3 predicts long-term mortality after ACS and identifies high-risk patients in a manner that is additive to clinical risk factors, troponin, and hs-CRP, possibly identifying myocardial ischemia with or without necrosis. -
Which low expression variant of FABP4 is associated with cardiovascular disease in type 1 diabetes?
Conclusions: In contrast to the general population, the low-expression G- allele of rs77878271 increased CVD risk in T1D, suggesting that genetically low FABP4 levels may be detrimental in the context of T1D.
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