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Bcl XL Prevents Apoptosis of Late Stage Erythroblasts but Does Not Bloodjournal Hematologylibrary Form
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People also ask
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What drug inhibits BCL2?
Venetoclax (ABT-199) is a BCL2 selective inhibitor and approved for use in CLL, SLL, and AML under the trade name VENCLEXTA®. ABT-737 inhibits BCL2, BCLXL, and BCLW (not shown). Similar to ABT-737, Navitoclax inhibits BCL-2, BCLXL, and BCLW but is orally bioavailable. -
Does venetoclax inhibit BCL-xL?
b As venetoclax does not target antiapoptotic MCL-1 and BCL-xL proteins, these proteins confer resistance via sequestration of BIM displaced from BCL-2. Epigenetic miR-377 downregulation by methylation results in increased expression of BCL-xL in resistant cells. -
How does Bcl-xL prevent apoptosis?
The anti-apoptotic members of this family, such as Bcl-2 and Bcl-XL, prevent apoptosis either by sequestering proforms of death-driving cysteine proteases called caspases (a complex called the apoptosome) or by preventing the release of mitochondrial apoptogenic factors such as cytochrome c and AIF (apoptosis-inducing ... -
What is the inhibitor of Bcl-xL?
We find that inhibition of the mitochondrial protein BCL-xL increases the propensity of cancer cells to die after treatment with a broad array of oncology drugs, including mitotic inhibitors and chemotherapy. -
How does Bcl-2 induce apoptosis?
By selectively binding to BCL-2, it inhibits the production of anti-apoptotic protein BCL-2 and activates the interaction of pro-apoptotic proteins BAK, BAX, and mitochondria, thereby releasing cytochrome C, activating the apoptosis pathway, and causing apoptosis to achieve the effect of treating cancer. -
What is the main function of Bcl-xL?
At mitochondria, Bcl-xL functions to prevent MOM permeabilization during apoptotic stress and also plays an important role in optimizing mitochondrial bioenergetic function through interactions with various membrane proteins (Vander Heiden et al., 2001; Alavian et al., 2011; Chen et al., 2011). -
What is a1331852 BCL-xL inhibitor?
A-1331852 is a potent and selectiveBCL-XL inhibitor with Ki value less than 0.01 nM for BCL-XL and 6 nM, 4 nM, 142 nM for Bcl-2, Bcl-W, MCL-1 respectively. It may be useful in the treatment of cancer, immune and autoimmune diseases. -
Does BCL-xL inhibit apoptosis?
The anti-apoptotic proteins Bcl-2 and Bcl-xL effectively inhibit KCN-induced cell death which is characterized by necrotic features including apparently intact chromatin, remarkable mitochondrial swelling with loss of crista structure and loss of plasma membrane integrity.
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