
Bcl XL Prevents Apoptosis of Late Stage Erythroblasts but Does Not Bloodjournal Hematologylibrary Form
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People also ask
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What is the function of BCL2 and Bcl-xL?
The antiapoptotic Bcl-2 family proteins Bcl-2 and Bcl-xL play important roles in inhibiting mitochondria-dependent extrinsic and intrinsic cell death pathways. It seems that these two proteins have distinct functions for inhibiting extrinsic and intrinsic cell death pathways.
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What does overexpression of Bcl-2 do?
Overexpression of BCL2 enhances survival of human embryonic stem cells during stress and obviates the requirement for serum factors | PNAS.
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How does Bcl-2 prevent apoptosis?
The anti-apoptotic members of this family, such as Bcl-2 and Bcl-XL, prevent apoptosis either by sequestering proforms of death-driving cysteine proteases called caspases (a complex called the apoptosome) or by preventing the release of mitochondrial apoptogenic factors such as cytochrome c and AIF (apoptosis-inducing ...
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What is the difference between Bcl-xL and BCL xS?
Regarding the protein, Bcl-xL is a 233-amino acid protein containing four BH domains, a loop between BH3 and BH4, and a transmembrane region. On the other hand, Bcl-xS lacks an internal 63-amino acid segment that contains the conserved BH1 and BH2 domains; therefore, it only contains the BH3 and BH4 domains.
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How does Bcl-xL prevent apoptosis?
The anti-apoptotic proteins, including BCL-2, BCL-XL, MCL-1, BCL-W and BFL-1/A1, can prevent MOMP and apoptosis by two complementary mechanisms. They can directly bind the BH3 domain of activator BH3-only proteins, preventing BAX and BAK oligomerization.
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How does a Bcl-2 inhibitor work?
A selective inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2), with potential pro-apoptotic and antineoplastic activities. Upon administration, Bcl-2 inhibitor BCL201 binds to and inhibits the activity of Bcl-2. This restores apoptotic processes in tumor cells.
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What is the difference between Bcl-2 and BCL-XL?
We noted both qualitative and quantitative differences in the functional activity of these two anti-apoptotic proteins in cells: Bcl-2 localized to the endoplasmic reticulum inhibits apoptosis induced by ceramide and thapsigargin but not by doxorubicin or TNFα, while Bcl-XL at the endoplasmic reticulum is active ...
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What is apoptosis of Erythroblasts?
The folate-deficient proerythroblasts underwent apoptosis, a form of programmed cell death, after 20-32 h in culture in folate-deficient medium. At the time of apoptosis the cells had differentiated into the later erythroblast stages and some had begun hemoglobin synthesis.
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