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Clathrin Coated Vesicle Assembly Polypeptides Physical Properties Ncbi Nlm Nih Form
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People also ask
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What are clathrin coated vesicles and what is their function?
Clathrin-coated vesicles were the first discovered and remain the most extensively characterized transport vesicles. They mediate endocytosis of transmembrane receptors and transport of newly synthesized lysosomal hydrolases from the trans-Golgi network to the lysosome.
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What is the role of clathrin in vesicular transport?
Clathrin constitutes the coat of vesicles involved in three receptor-mediated intracellular transport pathways; the export of aggregated material from the trans-Golgi network for regulated secretion, the transfer of lysosomal hydrolases from the trans-Golgi network to lysosomes and receptor-mediated endocytosis at the ...
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What is clathrin and what does it do?
Clathrin plays key roles in endocytic and endo-lysosomal membrane dynamics by facilitating the formation of coated vesicles at the plasma membrane and at the trans-Golgi network (TGN)/endosomal boundary.
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What is the function of the clathrin-coated vesicles?
Clathrin-coated vesicles were the first discovered and remain the most extensively characterized transport vesicles. They mediate endocytosis of transmembrane receptors and transport of newly synthesized lysosomal hydrolases from the trans-Golgi network to the lysosome.
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What are clathrin proteins central for?
Organizational Cell Biology Clathrin is the prototype self-assembling protein that coats transport vesicles during membrane traffic.
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What is the function of the vesicle coats?
Vesicle coat proteins, such as the archetypal clathrin and the coat protein complexes II and I (COPII and COPI, respectively) are molecular machines with two central roles: enabling vesicle formation, and selecting protein and lipid cargo to be packaged within them.
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How do clathrin coated vesicles select their cargo molecules?
Cargo receptors bind specifically to cargo proteins. Specific cargo molecules have a high affinity for clathrin. Cargo is selected randomly and is sorted later in the endosomes. Cargo is actively transported into preformed clathrin-coated vesicles.
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What do clathrin coated vesicles mainly transport proteins from?
Clathrin-coated vesicles, for example, mediate transport from the Golgi apparatus and from the plasma membrane, whereas COPI- and COPII-coated vesicles most commonly mediate transport from the ER and the Golgi cisternae (Figure 13-5).
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