Characterization of Different Isoforms of the HIF Prolyl Hydroxylase Biochemj

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everyone knows that life is impossible without oxygen in order to transport oxygen the human body needs red blood cells their production in the bone marrow is stimulated by a hormone called erythropoietin or epo for short and this hormone is produced in our kidneys when red blood cell counts or oxygen levels are low 30 years ago the mechanism which stimulates the kidneys to produce epo in response to decreased oxygen levels was still unknown it was only uncovered by the investigation of professor sir peter ratcliffe professor dr samanza and professor dr kailyn a groundbreaking discovery that earned them the nobel prize and opened a whole new field of therapeutic possibilities they identified the hypoxia inducible factor also called hif an essential factor for the transcription of several genes including epo so what exactly is hif and how does it work let's see under normoxic conditions the enzyme hef prolohydroxylase hydroxylates hif alpha this allows binding with the von hippel lindau