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Characterization of Different Isoforms of the HIF Prolyl Hydroxylase Biochemj

Characterization of Different Isoforms of the HIF Prolyl Hydroxylase Biochemj

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hello everyone my name is aparna ninthakrishnan and my lab partner today is alexis and our presentation today is on in silicon characterization of epigenetic inhibitors of dna methyltransferase and histone deacetylases on the hct-116 colorectal cancer cell line so covectal cancer is a type of cancer that originates in the colon or the rectum of the human body collectoral cancer is the third most common cancer in the world and approximately 52 and 580 deaths are expected from it in 2022 alone several different changes can cause cancer including dna hypermethylation dna methyltransferase 1 also known as dnmt1 is an important enzyme involved with the somatic inheritance of dna methylation and plays an important role in gene expression abnormal methylation is involved in the ethiology of human cancers especially hematological malignancies hypermethylation of dnmt1 which is characterized by too many methyl groups in the cytosine guanine also known as the cpg regions results in tumor suppres

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