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People also ask
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What is the phenotypic switch of vascular smooth muscle cells?
The phenotypic switch of VSMCs, which involves changing from a contractile state into a synthetic state (5), is accompanied by ECM damage and vascular inflammation under pathologic conditions, and has been demonstrated to be crucial in the development and progression of AA (4).
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What is the phenotype of smooth muscle cells?
Single nucleus per cell. No branches. No cross striations (no sarcomeres) Slow, rhythmic, prolonged contractions of visceral organs. Involuntary movement.
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What is the phenotypic diversity of smooth muscle cells?
The resulting phenotypic diversity of smooth muscle cells appears to be a function of innate genetic programmes and environmental cues, which include biochemical factors, extracellular matrix components, and physical factors such as stretch and shear stress.
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What is the characteristic of smooth muscle cells?
At a cellular level, smooth muscle can be described as an involuntary, non-striated muscle. Smooth muscle consists of thick and thin filaments that are not arranged into sarcomeres giving it a non-striated pattern. On microscopic examination, it will appear homogenous.
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What is the marker of smooth muscle cell?
Smooth muscle cells can be identified by several markers of their differentiation/maturation, including α-SMA, calponin, SM22, and SM-MHC isoforms (SM1 and SM2). Expression of SM-MHC isoforms is strictly limited to fully differentiated SMCs.
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What are the characterizations of smooth muscle?
SMC precursors first differentiate towards naive SMCs, which have a synthetic phenotype. The large majority of SMCs subsequently acquire a more contractile phenotype, although the extent of contractile differentiation differs and many cells retain a phenotype between synthetic and contractile.
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