
National Surveillance Laboratory Specimen Form for Possible Cases of Hantaviral Pulmonary Syndrome Diagnostic Specimen Submissio
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People also ask
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Is hantavirus pulmonary syndrome a reportable disease?
Hantavirus pulmonary syndrome (HPS) became a nationally notifiable disease in 1995 and is now reported through the Nationally Notifiable Disease Surveillance System (NNDSS) when fever is present in a patient with laboratory-confirmed evidence of hantavirus infection.
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What is the platelet count for hantavirus?
Platelets. Platelets initially may be normal, but a moderate and rapid decline in count usually is demonstrated, sometimes as early as the prodromal phase. In patients with Hantavirus cardiopulmonary syndrome (HCPS), 98% present with a platelet count of less than 150 X 109/L.
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How do you diagnose hantavirus pulmonary syndrome?
Because hantavirus resembles these infections, a blood test is often the only way to officially diagnose it. To diagnose hantavirus or HPS, clinicians should understand: Disease symptoms and rodent exposure history. Testing guidelines to identify the virus.
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What is the diagnostic criteria for hantavirus?
HPS: fever >101F (38.3C), chills, myalgia, headache, and gastrointestinal symptoms and one or more of: Bilateral diffuse interstitial edema, or Clinical diagnosis of ARDS, or Radiographic evidence of noncardiogenic pulmonary edema, or Unexplained respiratory illness resulting in death and on autopsy noncardiogenic ...
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What serum markers are associated with severity and outcome of hantavirus pulmonary syndrome?
Most importantly, we show that markers of intestinal damage and microbial translocation are increased during HPS, and that multiple serum markers, including interleukin (IL) 6 and intestinal fatty acid–binding protein (I-FABP), are associated with severity and fatal outcome.
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What is the serology of hantavirus?
The specific hantavirus serology testing is performed using enzyme linked immunosorbent assays (ELISAs) to detect IgG and IgM antibodies; molecular testing is done by RT-PCR. All hantavirus testing is performed at the National Microbiology Laboratory (NML).
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What is the pathology of hantavirus pulmonary syndrome?
The spleen in patients with HPS shows infiltration of immunocompetent cells within the red pulp and the periarteriolar sheaths. HPS can present clinically as noncardiogenic pulmonary edema. The pathophysiology of the pulmonary findings is that of a pulmonary capillary leak syndrome. The heart is not directly affected.
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What is the blood test for hantavirus pulmonary syndrome?
Testing. CDC uses an enzyme-linked immunosorbent assay (ELISA) to detect IgM antibodies and diagnose acute infections with hantaviruses. This diagnostic method is used to diagnose both HPS and HFRS.
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