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01 0623 DOC Form

01 0623 DOC Form

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[Music] the mechanism of resistance to cdk46 incubator uh is uh likely to be hetrogeneous uh and also in the setting uh post cdk46 incubator uh whether er uh in some patients might have lost you know what are the appropriate treatment for those patients um how to individualize uh patient therapy um based on their um you know resistant mechanisms I think uh it's really um you know hopefully would be uh something can be addressed uh in future uh research I think especially the patients who are uh early progressors or progress quickly on prior cdk46 Inhibitors what are the um potential treatment options you know should these patients go on uh for example uh chemotherapy the adcs or uh or uh you know immunotherapy or others I think uh we need to learn more about those patients uh in addition in patient who are without uh mutations in the pi3k pathway or er uh ESR for example uh what other Pathways uh that would uh be the best to um Target I think there are uh several targeted thera

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