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Defining the Emetogenicity of Cancer Chemotherapy Form
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People also ask
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What are the emetogenicity of chemotherapy agents?
Emetogenic chemotherapy drugs There are four levels of emetogenic drugs, categorized by risk of causing CINV: minimal (<10%), low (10–30%), moderate (30–90%), and high (>90%) [29].
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Is cyclophosphamide highly emetogenic?
Anthracycline-cyclophosphamide combinations are now classified as highly emetogenic. Lorazepam and diphenhydramine are useful adjuncts to antiemetic drugs, but are not recommended as single agents. Lorazepam or diphenhydramine are useful adjuncts to antiemetic drugs, but are not recommended as single agent antiemetics.
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How emetogenic is oxaliplatin?
Background: Oxaliplatin (OX), used primarily in gastrointestinal cancers, is considered moderately emetogenic while multiple guidelines classify carboplatin and cisplatin as highly emetogenic chemotherapy (HEC).
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What is the most emetogenic drug?
For example, highly emetogenic chemotherapy (HEC) regimens typically include high-dose cisplatin, carmustine, cyclophosphamide at doses greater than 1500 g/m2, dacarbazine, mechlorethamine, streptozocin, and combinations of anthracyclines and phosphamide (AC) [33].
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Is etoposide highly emetogenic?
Intravenous etoposide is listed as having low emetic potential. However, oral etoposide is categorized as having moderate emetogenicity.
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What is highly emetogenic chemotherapy?
Chemotherapy emetogenicity is classified as being: High: >90% incidence of emesis in absence of prophylaxis. Moderate: 30 to 90% incidence of emesis in absence of prophylaxis. Low: 10 to 30% incidence of emesis in absence of prophylaxis or. Minimal: < 10% incidence of emesis in absence of prophylaxis.
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What is moderately and highly emetogenic chemotherapy?
Highly emetogenic: medications or doses that cause CINV in >90% of patients. Moderately emetogenic: medications that induce CINV in 30% to 90% of patients. Low emetogenic: medications that are associated with CINV rates of 10% to 30% Minimally emetogenic: medications that cause CINV in <10% of patients.
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Which anticancer drug has high emetogenic potential?
Table 2. Emetogenic potentialCytotoxic drug High Cisplatin Cyclophosphamide Dacarbazine Mechloretamine34 more rows
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