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The Expression of Different Superoxide Dismutase Forms is Cell
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People also ask
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What is the difference between superoxide dismutase 1 and 2?
Soluble cytoplasmic SOD1 is a copper- and zinc-containing enzyme (Online Mendelian Inheritance in Man; OMIM, 147450). SOD2 is a mitochondrial matrix enzyme that scavenges oxygen radicals produced by the extensive oxidation-reduction and electron transport reactions that occur in mitochondria (OMIM, 147460).
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What is the function of superoxide dismutase in a cell?
Through their activity, SOD enzymes control the levels of a variety of reactive oxygen species (ROS) and reactive nitrogen species, thus both limiting the potential toxicity of these molecules and controlling broad aspects of cellular life that are regulated by their signaling functions.
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What are the variants of superoxide dismutase?
There are three major families of superoxide dismutase, depending on the protein fold and the metal cofactor: the Cu/Zn type (which binds both copper and zinc), Fe and Mn types (which bind either iron or manganese), and the Ni type (which binds nickel).
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What are the forms of superoxide dismutase?
There are three forms of superoxide dismutase present in humans, in all other mammals, and most chordates. SOD1 is located in the cytoplasm, SOD2 in the mitochondria, and SOD3 is extracellular. The first is a dimer (consists of two units), whereas the others are tetramers (four subunits).
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What is the reaction of superoxide dismutase?
Chemically, the dismutase activity of SODs accelerates the reaction of the superoxide anion (O2•−) with itself to form hydrogen peroxide (H2O2) and oxygen (2O2•−+2H+ → H2O2+O2; Fridovich, 1997). Superoxide is a negatively charged free radical formed through a single electron donation to oxygen (Hayyan et al., 2016).
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What are the three types of superoxide dismutase?
There are three distinct types of SOD isoenzymes, Mn-SOD, Fe-SOD, and CuZn-SOD, which are found in prokaryotes, microorganisms and plants, and eukaryotes, respectively. Also, there is an extracellular SOD (EC-SOD) that has been isolated and characterized from human extracellular fluid.
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What are the different forms of SOD?
Types of Sod Grass Bermuda grass sod: This sod grows into a thick turf and is used on golf courses. Bluegrass sod: This grass is usually deep green to blue in color. Centipede grass sod: This is a turf grass that's medium to light green color. Fescue sod: This sod is a soft grass designed for all-around living.
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What does the enzyme superoxide dismutase convert superoxide into ______?
Superoxide dismutases protect cells from reactive oxygen species by catalyzing the disproportionation of superoxide anion radicals into molecular oxygen and hydrogen peroxide.
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