A Novel Particulate Form of Ca2 CaMKII Dependent Protein

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in this movie we're going to consider the structural features of cam kinase 2 before discussing the structure of cam kinase 2 and why small and large calcium signals affect the kinase differently I show here an electron micrograph of a synapse on a spine spines recall are the small protrusions on the dendrites of cortical and hippocampal cells and are innervated by an axon terminal as shown at the figure on the right the electron micrograph shows both the presynaptic ending made by the axon terminal and the postsynaptic spine notice the density in the postsynaptic spine just below the axon terminal the density contains hundreds of different proteins among these are phosphatases such as calcineurin and the kinase Asst such as cam kinase 2 that are activated by the influx of calcium through NMDA receptors when the synapse is activated the point is that the proteins involved in synaptic weakening and synaptic strengthening that is long term depression and long term potentiation are locali