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well with that analysis there is look at the patients so the optic trial is this this study of monotony looking at three different doses at starting doses 45 30 and 15 and then with a mandatory reduction to 15 milligrams when the patients achieve a response and what this analysis does is look at the outcome by the mutation status of the patient so the overall analysis showed that 45 milligrams is the most effective of these doses in this analysis we focus on by specific mutation status one group is a T patient with a t359 the other one is patients with other mutations and the other one is patients with no mutations and it shows that for all these groups 45 milligrams seems to be still the best one but it's clearly relevant in the patients with the t359 that's when you see the biggest difference the response rate drops from like 60 percent for the primary endpoint to about 30 it's almost doubling the response um if you if you use 30 milligrams so that's v

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