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[Music] good afternoon everyone we're going to today talk about some general concepts about pathogenesis remember we defined this some time ago the mechanisms by which viruses cause disease so we're going to look at some general principles today we spend an entire course on this topic we we don't have that luxury but what we are going to talk about is important for understanding a lot of what we're going to discuss in the rest of this course to study pathogenesis you need an animal host you can't do it in cell culture well you can do perhaps you can do parts of it in cell culture but in the end you have to infect an animal and watch how disease develops depending on what aspect you want to look at you could look at antibody production in an animal But ultimately you're going to have to measure the efficacy of those antibodies in cell culture so there is some aspect of this that happens in plates of cells but for the most part we need anim

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