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[Music] they are very widely used for patients in the first-line setting or for patients who haven't been exposed to them for those patients who are treated with other agents in the first line in terms of differentiation between them I'm gonna go through the Paloma monarch and Mona Lisa studies and what you can see in regards to efficacy the trends for hazard ratio in regards to progression-free survival are very very similar across studies I think the largest differentiating factors really the different side effect profiles of the different medications specifically palos I clip and ribose I Club versus a fem acai Club a Bema cyclic is also unique in that there's data that suggests it has penetration to the nervous system so for patients who have brain metastases it might be a different option to think about the other differentiating agent with a been the psych lab is it can be given without endocrine therapy it can be given a single agent as well so it'

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