WPF PS 02 0200 Motion and Declaration for Order to Require Genetic Tests MTAF Washington Form

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hi I'm Megan Grove and today in this video we're going to be talking about a few Inc silico prediction tools that we use to computationally predict the effect of a variant on a protein or a gene um so for the purposes of today's video we're only going to be briefly touching on what insilico programs use to generate their predictions uh and then we're going to actually show how you input a variant into three commonly used tools polyphen mutation taster and sift um so for a more comprehensive list of the different tools that are out there because there are many um and how to really interpret that data I want to point you to the American College of medical genetics and genomics guidelines on sequence variant interpretation uh published in uh genetics and Medicine in Spring 2015 um because that has a very helpful list of many of the algorithms I have showing right here uh table two lists many of the missense and sply sight prediction uh tools that ar

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