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[Music] hello everyone I'm KY lenov I'm professor in neurochemistry at the University of gurg in Sweden I would like to welcome you to my presentation at the adpd it will be about blood and CSF biomarkers 4 ad and the path to the clinical implementation of these biomarkers as you know today we have the core adcf biomarkers including AA reflecting brain osis phosph to reflecting tow pathology by pet and also the neuro degeneration biomarket total tow or t very importantly these tests are available on fully automated lab analyzers and FDA approved methods with Superior Precision I will also tell you how these biomarkers perform in blood sampers indeed the a beta ratio shows concordance with ameloid pet but the problem is that there's only a minor change in positive cases with around a 10% decrease and this will lead to low robustness and risk of misdiagnosis but I will show you very promising data on plasma phosphotau with studies showing that PTO 241 shows the ea

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