Biointeractive the P53 Gene and Cancer Answer Key Form
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People also ask the p53 gene and cancer hhmi answers
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Is p53 good or bad?
The p53 protein is vital in maintaining DNA stability and preventing cancer. Normally, wild-type p53 protein (wtp53) binds to a negative regulator and is inactivated or degraded. However, when DNA damage occurs in a cell, the p53 protein is induced, causing the cell cycle to stop.
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What is the cause of p53-related cancer quizlet?
Without functioning p53 genes, cell proliferation is not regulated effectively and DNA damage can accumulate in cells. Those cells may continue to divide in an uncontrolled way, leading to tumor growth and/or cancer.
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What is the p53 gene and how can its mutation cause cancer Quizlet?
Tumor suppressor genes, such as p53, normally act like brakes. Mutations on the tumor suppressor genes can cause these brakes to fail. DNA repair genes normally function to fix minor damage to DNA when it is replicated. When DNA repair genes are mutated, DNA damage can accumulate and lead to cancer.
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What is the role of p53 in the cell cycle answer key?
The p53 protein arrests the cell cycle at two different times: before DNA replication (between phases G1 and S) and before cell division (between phases G2 and M). Arresting the cell cycle at these points helps prevent the division of cells containing damaged DNA, which could become cancerous.
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What cancer is caused by the p53 mutation?
Somatic Mutations. Somatic TP53 mutations occur in almost every type of cancer at rates from 38%–50% in ovarian, esophageal, colorectal, head and neck, larynx, and lung cancers to about 5% in primary leukemia, sarcoma, testicular cancer, malignant melanoma, and cervical cancer (Fig. 1).
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What activates p53 and what in turn does p53 do?
TP53 is activated in response to many stress stimuli, including activation of oncogenes and DNA damage. Upon activation, p53 directly regulates the transcription of ~500 genes and indirectly regulates many additional genes and thereby controls diverse cellular processes.
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What is the p53 gene and cancer answer?
p53 is a nuclear transcription factor with a pro-apoptotic function. Since over 50% of human cancers carry loss of function mutations in p53 gene, p53 has been considered to be one of the classical type tumor suppressors. Mutant p53 acts as the dominant-negative inhibitor toward wild-type p53.
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What is p53 expression in cancer patients?
The p53 protein was identified to be highly expressed in the ESCC tissue, with western blot analysis demonstrating that the expression level of p53 in the cancerous tissue was 1.89 times that of the tumor-adjacent normal tissue (P<0.001); furthermore, IHC indicated that there was a marked positive expression of p53 in ...
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