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well in this talk we're talking about pain physiology at the peripheral level and the story here begins with nociceptors noci CEP tors-10 OSA scepters are the peripheral receptors that detect a painful stimulus so a tissue which has got a lot of nociceptors is going to be very pain sensitive and a tissue without nociceptors is going to be pain insensitive because it's the nociceptors that first generate the pain so for example the dermis is pain sensitive because it contains nociceptors but the epidermis is paying insensitive because it doesn't contain nociceptors so you can cut the roof off a blister and the patients won't feel it because you're cutting off the epidermis it's only the dermis underneath which is sensitive this is why partial thickness injuries of the skin are so painful because you take away the epidermis without nociceptors and you expose the dermis which is full of nociceptors so there's lots of potential to gen

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