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People also ask
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What happens to the nuclear lamina and its associated lamins during cell division?
The nuclear lamina is completely disassembled during mitosis, following the phosphorylation of specific amino acids in the lamins, and then reassembled after mitosis (Ellenberg et al., 1997; Gerace and Blobel, 1980).
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What is the difference between nuclear lamina and lamin?
Primarily, the nuclear lamina provides structural support for the nucleus and the nuclear envelope; however, lamins and their associated proteins are also involved in most of the nuclear processes, including DNA replication and repair, regulation of gene expression, and signaling.
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What is the function of lamin B?
B-type lamins are expressed ubiquitously from early in embryonic development and regulate basic cellular functions, such as senescence, replication, spindle assembly, chromatin organization, transcription, and resistance to oxidative stress.
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What is the difference between lamin A and B lamins?
B-type lamins are constitutively expressed in most cell types, whereas A-type lamins are developmentally regulated, being predominantly expressed in most differentiated cell types [40]. However, certain cells of the hematopoietic system do not express A-type lamins even when fully differentiated [41].
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What are a-type and B-type lamins?
The two lamin subtypes also undergo distinct posttranslational modifications, with the B-type lamins retaining the addition of a farnesyl group, while this is not present in A-type lamins (7). A-type lamin expression is associated with differentiated mesenchymal cells and with stiffer cells and nuclei (8).
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What is the difference between lamin A and B1 lamins?
This suggests that A-type lamins are preferentially associated with gene-rich regions of active chromatin (Shimi, Pfleghaar, 2008). In contrast, LB1 seems to be mainly associated with the borders of regions with low gene density and low transcriptional activity.
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What are the different types of lamin proteins?
There are two major A-type lamin proteins (lamin A [LA] and C [LC]) and two major B-type lamins (LB1 and LB2). All vertebrate cells express at least one B-type lamin, whereas the A-types are developmentally regulated and expressed in differentiated cells [1,6].
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What are the A type and B type lamins?
The two lamin subtypes also undergo distinct posttranslational modifications, with the B-type lamins retaining the addition of a farnesyl group, while this is not present in A-type lamins (7). A-type lamin expression is associated with differentiated mesenchymal cells and with stiffer cells and nuclei (8).
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