Nuclear Lamins a and B1 Different Pathways of Assembly during Jcb Rupress Form

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Hello I'm Bob Goldman and in our previous talk I discussed the cytoskeletal intermediate filament networks of cells and now I'd like to introduce you to the nuclear lamins, which are the Type V intermediate filament proteins, which many consider to be the building blocks of nuclear architecture. And first, right on this introductory slide, you can see the lamin network, both forming an intense ring around the edge of the nucleus and in fact forming, in lesser concentrations, a network throughout the nucleoplasm. As I mentioned previously, nuclear lamins are Type V intermediate filament proteins. They are encoded by three genes: the nuclear lamin A gene, B1, and B2. And lamin C is an alternative splice product of the lamin A gene, so we have both lamin A protein, lamin C, lamin B1 and B2, in the nucleus of most vertebrate cells. Certainly human cells. Let me just go through the complexity of the intermediate filament processing, post-translation processing. Before I do, I just want to m