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Nuclear Lamins a and B1 Different Pathways of Assembly during Jcb Rupress  Form

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intermediate filaments are components of a cell's cytoskeleton and specialized members of the intermediate filament family known as lamins form a nuclear skeleton these proteins have been modified to allow them to localize to the inner nuclear membrane and self-assemble there to form a network of fibers just deep to the inner nuclear membrane known as the nuclear lamina lemons have such important roles in maintaining the structure of the nucleus determining the position of Chromatin and regulating gene expression that mutations in lemons can cause severe effects the effects of these are classified in a number of laminopathies which include defects in heart structure muscular dystrophy a number of cancers some lipid disorders which can include diabetes and fatty liver disease and other side effects many of the mutations cause effects which are so severe they are difficult to study because they cause the death of say infant mice which express these mutations they can result in ab

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