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I'm Ellen puree from the University of Pennsylvania in Philadelphia I'm the grace Lansing Lampert professor and chair of biomedical Sciences at the school of veterinary medicine and a professor of systems pharmacology and Therapeutics at the school of medicine at the University of Pennsylvania there are several manager issues when it comes to the important T-cell response these are T cells that can kill tumor cells in the context of cancer and one of the most important questions at the moment is can we convert the successes we've had in activating immune T cells and or adoptively transferring and genetically engineered T cells such as car T cells into patients and get them to both traffic to tumors and to function be functional in those tumors with and be effective killers in in the tumor setting we've seen this work very successfully in hematologic tumors but have had considerably less success so far in solid tumors I think today's sessions we&a

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