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People also ask
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What is the mechanism of peptide bond formation?
Peptide bonds are the vital links that connect amino acids to form polypeptide chains, which fold into functional proteins. These bonds are formed through a nucleophilic addition-elimination reaction and are characterized by their rigidity and planarity, thanks to resonance delocalization.
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How do proteins self-assemble?
Generally, some natural proteins are able to self-assembly via Van der Waals force, hydrogen bond, or hydrophobic interaction etc. into homomultimeric complexes with various symmetrical structures, such as β-clamps [24], α-hemolysin [25], catenanes [10], ferritins [26], vaults [8] and carboxysomes [27].
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What is the mechanism of peptide self assembly?
Peptide self-assembly is a naturally occurring process in which peptides spontaneously form ordered aggregates. This process is affected by ionic strength, pH, temperature, and interaction with cargos. Peptides can self-assemble to form nanofibers, nanotubes, nanoribbons and nanovesicles that can be loaded with drugs.
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What is the mechanism of the peptide reaction?
Peptides are chemically synthesized by the condensation reaction of the carboxyl group of one amino acid to the amino group of another. Protecting group strategies are usually necessary to prevent undesirable side reactions with the various amino acid side chains.
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What is the mechanism of peptide pore formation?
The mechanism of pore formation of lytic peptides, such as melittin from bee venom, is thought to involve binding to the membrane surface, followed by insertion at threshold levels of bound peptide.
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