Update on Pancreatic Intraepithelial Neoplasia Form

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growth and spread of panin lesions in three-dimensional space the pancreas is an organ located deep within the abdomen it is composed of acinar cells islets of langerhans and ducts acinar cells produce and secrete digestive enzymes these enzymes flow through progressively larger ducts and exit the pancreas into the duodenum pancreatic intraepithelial neoplasia or panin is an early non-invasive precursor to invasive pancreatic cancer pan ins are the result of genetic mutations in ductal cells they arise in pancreatic ducts smaller than five millimeters the normal cells lining the small ducts in the pancreas are gradually replaced by columnar epithelial cells they can be flat or papillary the nuclei enlarge and start to vary in size and shape cell clusters can bud from the table and the lesions multiply while pennants develop some are recognized as foreign by the immune system T lymphocytes are carried through blood vessels then migrate to the small duct here they kill the abnormal panin