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Structure, Function, and Regulation of a Subfamily of Mouse Zinc Form
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People also ask
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How does zinc affect gene expression?
Zinc alters gene expression mainly by binding to a site on the transcription factor. Genome-wide expression studies have shown early repression of genes related to zinc and immunity in adult patients with sepsis. -
What is the role of zinc in transcription factors?
Zinc finger proteins are transcription factors with the finger domain, which plays a signNow role in gene regulation. As the largest family of transcription factors in the human genome, zinc finger (ZNF) proteins are characterized by their different DNA binding motifs, such as C2H2 and Gag knuckle. -
What is the physiological role of zinc as an antioxidant?
Zn has been shown to have an antioxidant role(s) in defined chemical systems. Two mechanisms have been elucidated; the protection of sulfhydryl groups against oxidation and the inhibition of the production of reactive oxygens by transition metals. -
What is the intracellular concentration of zinc?
Although the intracellular Zn concentration signNowes 10–100 μM [39,40,41], the actual concentration of Zn in the cytosol is estimated to be quite low, perhaps in the pico-molar to low nano-molar range, because Zn binds a number of functional proteins in the cytosol and organelles and is also distributed into vesicles in ... -
What is intracellular zinc?
Intracellular zinc ([Zn]i) is maintained across a wide range of cells and species in a tight quota (100 to 500 μM) by a dynamic process of transport, intracellular vesicular storage, and binding to a large number of proteins (estimated at 3-10% of human proteome). -
What is the primary function of zinc?
Zinc is a trace mineral, meaning that the body only needs small amounts, and yet it is necessary for almost 100 enzymes to carry out vital chemical reactions. It is a major player in the creation of DNA, growth of cells, building proteins, healing damaged tissue, and supporting a healthy immune system. -
What is the role of zinc in DNA synthesis?
Hence, zinc may directly regulate DNA synthesis through these systems. Zinc also influences hormonal regulation of cell division. Specifically, the pituitary (GH)--like growth factor-I (IGF-I) axis is responsive to zinc status. -
What is the biochemical function of zinc?
It plays a role in cell division, cell growth, wound healing, and the breakdown of carbohydrates. Zinc is also needed for the senses of smell and taste. During pregnancy, infancy, and childhood the body needs zinc to grow and develop properly. Zinc also enhances the action of . -
What is the physiological function of zinc?
Zinc (Zn) is an essential trace mineral that regulates the expression and activation of biological molecules such as transcription factors, enzymes, adapters, channels, and growth factors, along with their receptors. -
How does zinc regulate gene expression?
Zn is able to alter expression by a comparable mechanism in which metal occupancy in a site on a transcription factor is necessary to increase the rate of transcription. Fe influences the abundance of specific mRNA by binding to proteins which interact with mRNA to enhance or repress their translation. -
What is the functional significance of zinc?
Zinc has three functions in zinc enzymes: catalytic, coactive (or cocatalytic) and structural [182], [183]. Because zinc is necessary for DNA replication and transcription and protein synthesis, this metal powerfully influences cell division and differentiation [24], [181]. -
What is the functional significance of zinc?
Zinc has three functions in zinc enzymes: catalytic, coactive (or cocatalytic) and structural [182], [183]. Because zinc is necessary for DNA replication and transcription and protein synthesis, this metal powerfully influences cell division and differentiation [24], [181]. -
What are the functions of zinc?
Zinc is involved in many aspects of cellular metabolism. It is required for the catalytic activity of hundreds of enzymes, and it plays a role in enhancing immune function, protein and DNA synthesis, wound healing, and cell signaling and division [1-4].
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