
Structure, Function, and Regulation of a Subfamily of Mouse Zinc Form
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People also ask
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What is a zinc transporter?
Zinc transporters (ZnT) form an important class of zinc efflux proteins in mammals. Nine ZnT transporters, designated ZnT1–ZnT8 and ZnT10, have been identified to date. Recent reports have established that the ZnT transporters are localized to various intracellular compartments and the plasma membrane.
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What are the structural functions of zinc?
The requirement of Zn for cell proliferation is supported by its structural and catalytic functions in enzymes related to DNA synthesis, transcription, and ribosomal function, as well as its role as a mitogenic signal messenger [3,35].
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What are the intestinal transporters of zinc?
The zinc transporter ZIP4 plays an essential role in dietary zinc uptake [50] (Fig. 2a). ZIP4 is expressed throughout the small intestine, and thus appears to impact zinc absorption in all intestinal regions. ZIP4 is localized on the apical membrane of the villus epithelium and mediates zinc transport from the lumen.
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What are zinc transporters?
Zinc transporters (ZnT) form an important class of zinc efflux proteins in mammals. Nine ZnT transporters, designated ZnT1–ZnT8 and ZnT10, have been identified to date. Recent reports have established that the ZnT transporters are localized to various intracellular compartments and the plasma membrane.
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What is zinc transporter antibody?
Zinc transporter 8 (ZnT8) is an islet β-cell secretory granule membrane protein recently identified as an autoantibody antigen in type 1 diabetes. The aim of this study was to determine the prevalence and role of antibodies to ZnT8 (ZnT8As) in adult-onset diabetes.
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What are the zinc transporters in humans?
In humans, two major zinc transporter families, the SLC30 (ZnT) family and SLC39 (ZIP) family control cellular zinc homeostasis. This review will focus on the SLC39 transporters. SLC39 transporters primarily serve to pass zinc into the cytoplasm, and play critical roles in maintaining cellular zinc homeostasis.
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