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CHEMISTRY and TOXICOLOGY of PERCHLORATE Form
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People also ask
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How much perchlorate is toxic?
The EPA has developed a Reference Dose (RfD) of 0.0007 mg/kg/day for perchlorate. The RfD is an estimate of a daily oral exposure to the human population (including sensitive subgroups) that is likely to be without appreciable risk of deleterious effects during a lifetime.
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What do perchlorates do to the body?
Perchlorate affects the ability of the thyroid gland to take up iodine. Iodine is needed to make hormones that regulate many body functions after they are released into the blood. Perchlorate's inhibition of iodine uptake must be great enough to affect the thyroid before it is considered harmful.
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How is perchlorate toxic?
Perchlorate impacts human health by interfering with iodide uptake into the thyroid gland and the production of thyroid hormone. Thyroid hormone is needed for prenatal and postal growth and development, as well as for normal metabolism and mental function.
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Is perchlorate a hazardous substance?
Sodium Perchlorate is a white sand-like solid. It is used in explosives, jet fuels, as a medication, and to make other chemicals. * Sodium Perchlorate is on the Hazardous Substance List because it is cited by DOT. * This chemical is on the Special Health Hazard Substance List because it is REACTIVE.
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What is the problem with perchlorate?
The primary toxicity issue is associated with disruption of iodide uptake in the thyroid gland due to its similarity in ionic radius to iodide. Widespread presence of perchlorate in drinking water aquifers and its toxicological properties make perchlorate an emerging chemical of concern.
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What foods have perchlorate in them?
Scientists have found perchlorate in items like milk and leafy greens. That doesn't mean you should avoid these foods.
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Are perchlorates toxic to humans?
Since thyroid hormone is required for development and function of many tissues in the body, including the brain, perchlorate is considered a serious threat to human health and water resources. Note that other chemicals, including nitrate can also inhibit iodine uptake by the thyroid.
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What diseases are caused by perchlorate?
Although not demonstrated in humans, it is anticipated that people exposed to excessive amounts of perchlorate for a long time may develop a decreased production of thyroid hormones. The medical name for this condition is hypothyroidism.
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