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CHEMISTRY and TOXICOLOGY of PERCHLORATE Form
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What are the effects of perchlorate?
At high concentrations perchlorate can affect the thyroid gland by inhibiting the uptake of iodine. A maximum contaminant level has not been set, while a guidance value of 6 ppb has been suggested by Health Canada. Perchlorate is measured in environmental samples primarily by ion chromatography. -
What is the chemical test for perchlorate?
N-Phenylanthranilic Acid It is added to some concentrated sulphuric acid. A red, orange or yellow colour indicates the presence of Chlorate in a Perchlorate sample. The test is fairly sensitive. Mix about 0.1g of the phenylanthranilic acid with about 15cc concentrated Sulphuric acid to give a blackish/blueish solution. -
Why are perchlorates hazardous to life?
The major toxic effect of perchlorate in humans is thyroid disruption. Perchlorate competitively inhibits the sodium-iodide symporter (NIS), an intrinsic membrane glycoprotein responsible for the uptake of iodide into the thyroid and other organs. -
How is perchlorate toxic?
At high concentrations perchlorate can affect the thyroid gland by inhibiting the uptake of iodine. A maximum contaminant level has not been set, while a guidance value of 6 ppb has been suggested by Health Canada. Perchlorate is measured in environmental samples primarily by ion chromatography. -
What are the uses of perchlorate in chemistry?
Perchlorates are used in a number of applications including as an oxidizer in solid rocket fuel and as a component of fireworks, pyrotechnics, flares and explosives. Other uses include as a pharmaceutical for hyperthyroid, as a gas generator, as an electrolyte for lithium cells, and as a chemistry reagent. -
How is sodium perchlorate harmful to humans?
Higher levels can cause trouble breathing, collapse and even death. * High or repeated exposure to Sodium Perchlorate can affect the kidneys and red blood cells, causing anemia (low blood count). * Sodium Perchlorate is a REACTIVE CHEMICAL and an EXPLOSION HAZARD. -
What is the animal toxicology for perchlorate?
The thyroid gland is also the main target organ for perchlorate toxicity in animals. The thyroid changes caused by perchlorate in animals may lead to tumors in the thyroid after a long period. This has occurred after administering high amounts (928 to 2,573 milligrams perchlorate/kg/day) of perchlorate to the animals. -
Is perchlorate a carcinogen?
How likely are perchlorates to cause cancer? There are no studies of exposure to perchlorates and cancer in humans. Long-term exposure to perchlorates induced thyroid cancer in rats and mice, but there are reasons to believe that humans are less likely than rodents to develop this type of cancer.
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