
M0 07750 Multiprotein Complex Formation at the Myosin Heavy Jbc
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People also ask
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What are the myosin heavy chain isomers?
Genetic and Molecular Basis of MHC Isoforms In humans, these genes include MYH7 (β-MHC), MYH6 (α-MHC), MYH1 (IIx MHC), MYH2 (IIa MHC), and MYH3 (embryonic MHC), among others. Each gene has unique regulatory elements that control its expression in specific muscle types and developmental stages.
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What is embryonic myosin heavy chain?
Myosin heavy chain-embryonic (MyHC-emb) is a skeletal muscle- specific contractile protein expressed during muscle development. Mutations in MYH3, the gene encoding MyHC-emb, lead to Freeman– Sheldon and Sheldon–Hall congenital contracture syndromes.
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What are the isoforms of the myosin heavy chain?
Two isoforms of myosin heavy chain (α and β) are expressed in the heart and their relative proportions are affected by many pathophysiological stimuli. Normal heart of adult rodents contains α-myosin heavy chain that differs from fetal β-myosin heavy chain for faster cross-bridge kinetics and less tension generated.
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What is the actin myosin complex formation?
Formation of cross-bridges between actin and myosin occurs ubiquitously in eukaryotic cells and mediates muscle contraction, intracellular cargo transport, and cytoskeletal remodeling.
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What are the isoforms of muscle fibers?
The MHC 1 isoform is expressed in slow-twitch fibers of skeletal muscle and in ventricular myocardium, and three fast isoforms (2A, 2X, and 2B) are expressed in fast-twitch fibers. Other isoforms appear to be expressed in muscle in a species-specific manner.
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What are the isoforms of smooth muscle myosin?
Alternative splicing of the primary transcript from a single gene generates four smooth muscle myosin heavy chain isoforms. These isoforms differ both at the carboxyl terminus (SM1 and SM2 isoforms) and at the amino terminus (SM-A and SM-B isoforms).
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What are the cardiac myosin isoforms?
In the healthy human heart, the ventricles express predominantly β-myosin while the atria express predominantly the α-isoform. The two myosin isoforms, α and β, although 91% identical in motor domain sequence [1], have distinct mechanical and biochemical properties.
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What is myosin heavy chain protein?
Myosin heavy chain (MHC) is the motor protein of muscle thick filaments. Most organisms produce many muscle MHC isoforms with temporally and spatially regulated expression patterns. This suggests that isoforms of MHC have different characteristics necessary for defining specific muscle properties.
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