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Structure, Spacing, and Phasing of Nucleosomes on Isolated Forms
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People also ask
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What is the process of the nucleosome?
The nucleosome assembly reaction has two steps: histones H3 and H4 are deposited onto DNA as an H3/H4 tetramer in the first step, to form a nucleosome precursor; in the second step, the nucleosome is com- pleted by the association of two H2A/H2B dimers with this precursor. -
What is the spacing between nucleosomes?
Eukaryotic chromosomes are composed of chromatin, in which regularly spaced nucleosomes containing ~147 bp of DNA are separated by linker DNA. Most eukaryotic cells have a characteristic average nucleosome spacing of ~190 bp, corresponding to a ~45 bp linker. -
What happens to nucleosomes during transcription?
During transcription elongation nucleosomes are acetylated and transferred behind RNA polymerase II where they are required to suppress spurious transcription initiation within the body of the gene. -
What is the function of the nucleosomes?
Nucleosome A nucleosome is the basic repeating subunit of chromatin packaged inside the cell's nucleus. In humans, about six feet of DNA must be packaged into a nucleus with a diameter less than a human hair, and nucleosomes play a key role in that process. -
What is the phasing of nucleosomes?
The phenomenon of "nucleosome phasing" describes nucleosomal arrays that are generated through positioning of nucleosomes by the underlying DNA sequence. -
What is the structure of the nucleosomes?
The nucleosome is the fundamental subunit of chromatin. Each nucleosome is composed of a little less than two turns of DNA wrapped around a set of eight proteins called histones, which are known as a histone octamer. Each histone octamer is composed of two copies each of the histone proteins H2A, H2B, H3, and H4. -
What are the turns of DNA around nucleosomes?
Each nucleosome is composed of a little less than two turns of DNA wrapped around a set of eight proteins called histones, which are known as a histone octamer. Each histone octamer is composed of two copies each of the histone proteins H2A, H2B, H3, and H4. -
What is the structure of a nucleosome the basic unit of DNA packing in eukaryotic cells?
A nucleosome is the basic structural unit of DNA packaging in eukaryotes. The structure of a nucleosome consists of a segment of DNA wound around eight histone proteins and resembles thread wrapped around a spool. The nucleosome is the fundamental subunit of chromatin.
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