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this trial was a trial in which patients who were between the ages of eighteen sixty who I'd newly diagnosed AML and who were shown to have a flip three mutation in their blast prior to enrollment on the studies there's a bit of a trick right we had to scream 3300 patients around the world to find 880 about that had the flip through mutation of whom about 717 were randomized to either 3 plus 7 plus placebo or 3 plus 7 plus minus torrent at 50 milligrams twice a day and patients were randomized an induction also that they're placebo or minus one was carried on throughout consolidation with high-dose heresy and there was also a maintenance of 12 months of minus torn or placebo tacked on at the end of all the therapy so it really was standard chemo plus I minus minus torn fortissimo so this met its primary endpoint the trial was positive for survival and those who were randomized to Midas Torin there was a twenty three percent reduction in the risk of dying if you were randomized to the M