A Proteolytic Pathway that Controls the Cholesterol Content of Pnas Form

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previously we talked about the by synthesis of cholesterol and we saw how complicated this process actually is well now we're going to switch to the regulation of cholesterol synthesis and we'll see that this actually is not very complicated so the most important thing you have to take away from this lesson is the regulation of cholesterol since synthesis occurs at the level of the rate-limiting enzyme HMG co-reductase so as we'll talk about all these different regulatory methods remember this fact to increase the production of cholesterol we have to increase the expression of HMG co-reductase to decrease the production of cholesterol we have to decrease the expression of hmg-coa reductase so let's begin with sterile dependent regulation so let's suppose within our body specifically within the liver cells we have low levels of cholesterol if we have low levels of cholesterol that stimulates the proteolytic cleavage of an important transcription factor off the ER membrane so this is the