Metabolic Inflexibility in Skeletal Muscle with Obesity Form

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[Music] over consumption of nutrients can be a precursor to what we call metabolic inflexibility mitochondrial dysfunction and dysregulation of metabolic health this paper summarizes potential mechanisms by which excess fuel and insulin resistance may result in metabolic and flexibility obesity as well as dysregulation and overall cardiometabolic health my name is dr biff palmer and on behalf of my co-author dr deborah clegg i invite you to read an upcoming paper in the mayo clinic proceedings entitled metabolic flexibility and its impact on health outcomes now we define metabolic flexibility as the ability to rapidly switch between what is called the absorptive and the post-absorptive state the absorptive state describes that situation immediately after a meal in that situation as you well know glycolysis and pyruvate oxidation are the main sources of fuel a byproduct of that metabolism is the formation of malonyl coa that it suppresses fatty acid oxidation on the other hand in a post