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Metabolic Inflexibility in Skeletal Muscle with Obesity Form
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People also ask
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What 3 body systems are affected by being overweight?
Being overweight or obese can have a serious impact on health. Carrying extra fat leads to serious health consequences such as cardiovascular disease (mainly heart disease and stroke), type 2 diabetes, musculoskeletal disorders like osteoarthritis, and some cancers (endometrial, breast and colon).
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What causes metabolic inflexibility?
A large body of evidence suggests that overnutrition and unabated substrate competition lead to a state of metabolic insensitivity and inflexibility, characterized by distorted nutrient sensing, blunted substrate switching, and impaired energy homeostasis.
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How does obesity affect the skeletal system?
In fact, obese people are more likely to fall and break bones than people of normal weight. Especially when BMI is over 30, obesity has limited protection against fractures and may even increase the risk of fractures (Kang et al., 2015).
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What metabolic abnormalities are associated with obesity?
The metabolic complications of obesity, often referred to as the metabolic syndrome, consist of insulin resistance, often culminating in β-cell failure, impaired glucose tolerance and type 2 diabetes, dyslipidemia, hypertension, and premature heart disease.
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How does obesity affect the muscular system?
Obesity is associated with functional limitations in muscle performance and increased likelihood of developing a functional disability such as mobility, strength, postural and dynamic balance limitations.
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What are metabolic alterations in obesity?
The most common complications involve alterations in metabolic function that are risk factors for cardiovascular disease, namely hyperglycemia, hyperinsulinemia, and glucose intolerance, liver fat accumulation, dyslipidemia (increased serum triglyceride and decreased serum HDL-cholesterol concentrations; a predominance ...
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How does obesity affect the skeletal and muscular systems?
Skeletal and muscular systems Obesity can cause deteriorating bone density and muscle mass. This is referred to as osteosarcopenic obesity. Osteosarcopenic obesity can lead to a higher risk of fractures, physical disability, insulin resistance, and poorer overall health outcomes.
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How does the muscular system affect the skeletal system?
These muscles help hold the skeleton together, give the body shape, and help it with everyday movements (known as voluntary muscles because you can control their movement). They can contract (shorten or tighten) quickly and powerfully, but they tire easily.
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