TNF and TNF Receptor Expression and Sensitivity in Human Form

Instructions and help about TNF And TNF Receptor Expression And Sensitivity In Human

in this video of cell signaling we will be discussing about necroptosis it is a signaling pathway which leads to cell execution through the tumor necrosis factor then necroptosis is programmable form of necrosis just like we have apoptosis which is gas space dependent programmed cell death in the same way we have necrotosis which is gas-based independent programmed cell death both the pathways are mediated through tnfr1 that's tumor necrospector receptor one to start the necroplasty signaling pathway we see we have the cell membrane and in the cell membrane we have the tnf receptors in the form of monomoles distributed over the plasma membrane as shown in the diagram in the structure of tnf r1 it has got that domain to its intracellular side and this that domain mediates downstream signaling but this domain remains inhibited by the action of another protein called sodd that silencer of that domain now let's initiate the signaling first of all the tnf alpha molecules which are the signa