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IGE13 Contract National Final Cdr Form
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People also ask
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Where does somatic hypermutation occur in the body?
Somatic hypermutation only happens in activated B cells, and not in T cells. This happens at sites where B cells are activated and T cells are also present- basically in germinal centers within lymph nodes and the spleen.
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Where does somatic hypermutation occur?
The germinal centers of peripheral lymphoid tissues are the sites where somatic hypermutation, positive selection and differentiation of B cells with high-affinity receptors occur. Germinal centers are the only places in the body where antigen is retained for months or years in an extracellular location.
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Where do B cells undergo somatic hypermutation?
Somatic hypermutation (SHM) is a highly mutagenic process that occurs in antigen-stimulated B cells in the germinal centres of the immune system.
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Where in the germinal center does somatic hypermutation occur?
Somatic hypermutation (SHM) is the incorporation of point mutations within the immunoglobulin V-region genes, which serve as the basis for affinity maturation and effective immune responses. The process is initiated by antigen stimulation, occurs in the dark zone of germinal centres, and requires functional AID [49].
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What is the rate of somatic hypermutation?
With T-cell help, the variable domain genes of germinal center lymphocytes undergo somatic hypermutation (SHM) at a rate of up to 10-3 changes per base pair per cell cycle. SHM is correlated with transcription of the locus, and recent studies have suggested that at least two separate mechanisms are involved.
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Does somatic hypermutation occur in the dark zone?
It is believed somatic hypermutation occurs in the dark zone of the germinal centre, but when centroblasts stop proliferating and develop instead into centrocytes they increase their expression of certain surface receptors and move towards the light zone.
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