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 PVDOMICS STUDY Annual Follow Up Form #187 2023-2025

2023-2025 Form

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the BP 41072 study is a combination study um for patients with relapsed refractory uh B cell lymphomas both indland and aggressive B cell lymphomas and it's a combination of gamap a bispecific CD3 cd20 antibody together with a bispecific co-stimulatory fusion protein called enuma fusp Alpha which Targets cd19 on the B cells on the tumor cells and 41 BB like end on the effector cells predominantly here the tea cells with this combination we want to not necessarily deepen the responses to gamap which are already frequent and deep but we mainly want to prolong the the uh the responses and this is what the preclinical data uh promised and this is also what we see now both with the clinical responses and with the uh pharmacodynamic analyses which are presented here at Ash so in a relatively large population of more than 130 patients included we see overall responses in uh in the vast majority of patients including complete responses in 57% of patients so it's actually more t

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