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People also ask
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What is the Cntnap2 mouse model of autism?
Cntnap2 mutant mice show deficits in the three core domains of ASD: reduced vocal communication, repetitive and restrictive behaviors, and abnormal social interactions. In addition, they show hyperactivity and epileptic seizures [41], both features described in CDFE patients.
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What is the mouse model for ASD?
The BTBR T+tf/J mouse model has been reported to exhibit several symptoms of ASD, including reduced social interactions and anxiety compared to other inbred strains. Additionally, the brain anatomy in this mouse model has previously revealed profound abnormalities compared to regular strains, such as C57Bl/6J mice.
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What is the BTBR mouse model of autism?
The inbred BTBR T+tf/J (BTBR) mouse strain has been used as an animal model of core behavioral deficits in autism. BTBR mice exhibit repetitive behaviors and deficits in sociability and communication, but other aspects of their cognitive phenotype, including attentional performance, are not well characterized.
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What are the neurodevelopmental disorders of the mouse model?
Mice models exhibit several human NDD-related behavioral deficits including cognitive impairments, defects in learning and memory, hyperactivity and autism-like behaviors, but others cannot be precisely recapitulated, suggesting that assessment of higher brain functions in the lissencephalic brain is challenging.
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What is the mouse model for psychiatric disorders?
Within neurodevelopmental theory (Tucker and Luu, 2012), each cognitive process is an extension of neural development: each thought can only emerge on the Bayesian foundation of the neural priors of personal ontogenetic history.
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What are the five neurodevelopmental disorders?
A mouse model is a laboratory mouse used to study some aspect of human physiology or disease. A variety of different model organisms are used in this regard, but mice are especially useful because they share mammalian features with humans and suffer from many of the same diseases.
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What is the mouse disease model?
A psychiatric disorder is regarded as a black box, impossible to model in mice. However, some of the associated traits, often called intermediate traits, can be modeled in mice. Associated traits from many diverse areas of neuroscience are shown here for the example of schizophrenia.
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