Mo 99 Misc 2022-2025 Form
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What is the global shortage of technetium-99m?
The global shortage of Tc-99m stems for issues related to its production. Normally, Tc-99m decays and is eluted from Molybdenum-99, which is generated from a high-flux reactor. The parent isotope Molybdenum-99 is only produced in a few nuclear reactors worldwide, such as in Petten, Netherlands.
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What does molybdenum-99 do?
Mo-99's decay product, technetium-99m (Tc-99m), is used in over 40,000 medical procedures in the United States each day to diagnose heart disease and cancer, to study organ structure and function, and to perform other important medical applications.
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Why is technetium-99m used in medicine?
Tc-99m is the preferred tracer for a number of scans used in medicine worldwide to help diagnose medical conditions. Tc-99m scans are used to detect a wide range of conditions including injuries, infections, tumours, heart disease, thyroid abnormalities, kidney conditions and also to guide some cancer procedures.
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What is the decay of Mo-99?
Molybdenum-99 is an unstable radioactive isotope and thus eventually decays into other elements. With a half-life of 66 hours, it takes just under three days for half of any given quantity of Mo-99 to decay into technetium-99m.
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What is the specific activity of molybdenum-99?
~900 Ci of 99Mo at reactor discharge having a specific activity of~-,60,000 Ci/g molyb- denum. Subsequent decay of the 99Mo during the recovery and purification procedure reduces the specific activity to ~20,000 Ci/g molyb- denum.
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What is the half-life of Mo-99?
Enter physics. Nuclear medicine usually operates on the premise of radioactive isotopes that come with an expiration date; Tc-99m has a half-life of only six hours.
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What is a threat to the Mo-99 supply chain?
The greatest single threat to supply reliability is the approaching obsolescence of the aging reactors that current large-scale producers utilize to irradiate HEU targets to obtain Mo-99 (see IAEA, 2008).
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Why is there a shortage of molybdenum?
The shortage is a result of unexpected required maintenance on the high-flux reactor (HFR) in Petten, Netherlands. A reactor inspection determined that a previously identified pipe deformation must be corrected immediately, rather than as a planned fix scheduled for the December 2024 maintenance period.
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