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[Music] so you have two different forms of maturation you have nuclear maturation which requires DNA replication which requires Foley but as I mentioned earlier you also have cytoplasmic differentiation or maturation now that is more due to RNA which doesn't need folate as much and so then what happens is if somebody is deficient in folate or b12 or both because they work so closely together that what you get is when the nucleus is trying to mature and then replicate DNA in order to divide it can't the cytoplasm which doesn't require folate because it's using RNA does mature and so what happens is and I mentioned this before it a cell just doesn't necessarily split what happens is is it wants to make sure that these cells after they split have sufficient cytoplasm so it the cytoplasm matures in preparation for division so that each cell has enough cytoplasm but what happens is is if the nucleus can't mature if it can't replicate its DNA then the cell can't divide and then what happens

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