STATS TRANSCRIPTIONAL CONTROL and BIOLOGICAL IMPACT Form
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People also ask
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What is STAT in cell biology?
STAT proteins are latent cytoplasmic transcription factors that can be induced by cytokines and growth factors [1,2]. There are seven STATs (STAT1,-2,-3,-4,-5a,-5b,-6) in mammalian cells and all of them have individual and overlapping functions and regulators in vivo [3].
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What is the function of the STAT gene?
Normal Function These genes provide instructions for making proteins that are part of essential chemical signaling pathways within cells. When STAT proteins are turned on (activated) by certain chemical signals, they move into the cell's nucleus and attach (bind) to particular areas of DNA.
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What is the activation of STAT?
Protein tyrosine kinases activate the STAT (signal transducer and activator of transcription) signaling pathway, which can play essential roles in cell differentiation, cell cycle control, and development. However, the potential role of the STAT signaling pathway in the induction of apoptosis remains unexplored.
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What is the function of STAT?
Members of the signal transducer and activator of transcription (STAT) protein family are intracellular transcription factors that mediate many aspects of cellular immunity, proliferation, apoptosis and differentiation. They are primarily activated by membrane receptor-associated Janus kinases (JAK).
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What is transcriptional control and why is it important?
Transcriptional regulation is a critical biological process that allows the cell or an organism to respond to a variety of intra- and extra-cellular signals, to define cell identity during development, to maintain it throughout its lifetime, and to coordinate cellular activity.
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What does STAT do in cells?
STAT proteins are transcription factors that are activated by external signals. When activated, they can increase the transcription of certain genes, leading to uncontrolled cell growth, anti-cell death responses, and the formation of blood vessels.
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What is the function of STAT?
Members of the signal transducer and activator of transcription (STAT) protein family are intracellular transcription factors that mediate many aspects of cellular immunity, proliferation, apoptosis and differentiation. They are primarily activated by membrane receptor-associated Janus kinases (JAK).
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What does STAT stand for in immunology?
Immune dysregulation occurs when the immune system cannot exert control over inflammation, leading to severe inflammatory complications. Two of these disorders are called STAT1 gain of function (GOF) disease and STAT3 gain of function (GOF) disease. STAT stands for signal transducer and activator of transcription.
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