Stanford Hospital & Clinics Antibiotic Dosing Reference Guide Form
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People also ask
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Why are antibiotics dosed by weight?
As they highlight, “[s]everal physiological alterations reported in obesity can affect the processes of distribution, protein binding, metabolism, and clearance of antimicrobial agents.” That is, overweight patients may need larger doses for the medication to be effective, in the same way that underweight patients may ... -
Are antibiotics dosed by weight?
The usual dose is 20 to 40 milligrams (mg) per kilogram (kg) of body weight per day, divided and given every 8 hours, or 25 to 45 mg per kg of body weight per day, divided and given every 12 hours. Infants 3 months of age and younger—Dose is based on body weight and must be determined by your doctor. -
Why are loading doses given?
If therapeutic effects are needed quickly, and the drug has a long half-life, one can use a loading dose to achieve therapeutic levels on the first dose. The loading dose rapidly achieves the therapeutic response and subsequent doses maintain the response. -
How does obesity affect drug dosing?
Obesity also has an effect on the gastric emptying and gut permeability, meaning that drugs are absorbed at different rates to normal. Drug penetration into tissue is also affected, meaning that a higher dose may be needed in order to signNow effective concentrations. -
What are antibiotic loading doses?
In pharmacokinetics, a loading dose is an initial higher dose of a drug that may be given at the beginning of a course of treatment before dropping down to a lower maintenance dose. -
What is antibiotic loading?
The loading dose is probably the most important dose and is a function of the volume of distribution of the drug and the desired plasma concentration but independent of renal function. Antibiotics are classified in a number of ways that have implications for dosing. -
What is the antimicrobial restriction policy?
An antimicrobial restriction and preauthorization is a strategy by which the medical staff should obtain approval for the use of specific restricted antimicrobial agents before prescription to ensure appropriate antimicrobial use. -
What are the doses of IHD?
Usual Dosing (Adults) Usual: 1 gram IV q8h. Complicated skin/skin structure infections: 500 mg IV q8h. -
When calculating drug dosages for obese patients the drug dosages should be?
As clearance increases with body size, the dose should be increased in morbid obesity and suggested doses include 30–40 mg twice daily. -
How should antibiotics be dosed in obesity?
Recommended antimicrobial dosing in obesity (assumes normal renal function). Consider upper limit of normal dosing in severe infections, for example, 2–3 g IV every 8 h (option for continuous infusion), or 1.5–2 g every 6 h intermittent dosing.
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