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Structure Activity Relationship of Paracetamol PPT Form

Structure Activity Relationship of Paracetamol PPT Form

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Instructions and help about paracetamol sar

paracetamol is a periaminophenyl derivative these derivatives possess analgesic and antiparetic action but lack anti-inflammatory effects paracetamol exists as white crystalline powder sparingly soluble in water soluble in alcohol and very slightly soluble in methylene chloride paracetamol produce antibiotic effect by acting on the hypothalamic heat regulating center in brain and analgesia by elevating the pain threshold usual oral adult dose of paracetamol is 500 milligrams to one gram for three or four times a day now before moving towards sar of paracetamol let's look at the structure of paracetamol firstly aminophenol ring is essential for antiparetic activity of paracetamol amino and hydroxyl group in benzene ring both should be at para position presence of these group at any other position on ring result in loss of activity if both hydroxyl group and acetyl group is removed from ring compound become aniline which is more toxic if only hydroxyl group is removed from ring we get a

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