
Triple Helix Formation with the Promoter of Human 1I Procollagen Gene by an Antiparallel Triplex Forming Oligodeoxyribonucleotid
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People also ask
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What is triple helix formation?
A triple helix refers to the structure formed by the binding of a third strand to a duplex DNA through Hoogsteen base pairing, involving stable triplex structures with specific base sequences. AI generated definition based on: International Review of Cell and Molecular Biology, 2014.
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What is an example of a triple helix?
Openness and transparency are critical :While Silicon Valley is one of the most cited examples of the triple helix model of innovation at play, there is a model that pre-dates its rise -Route 128; an ~100 km highway around Boston in the eastern United States.
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What is the form of DNA that consists of a triple helix promoted by acid conditions and runs of purine bases called?
For example, H-DNA, or intramolecular triplex DNA is a structure in which half of the pyrimidine tract swivels its backbone parallel to the purine strand in the underlying duplex, or the purine strand (in *H-DNA) binds to the purine strand of the underlying duplex in an antiparallel orientation, to form a triple ...
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What does it mean to have a triple helix DNA?
A DNA triplex is a helical structure composed of three strands in which a single DNA strand binds to the major-groove of a Watson–Crick duplex. The third strand bases hydrogen-bond to the duplex purine strand, forming Hoogsteen or reverse Hoogsteen pairs.
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What is the significance of the triplex DNA?
Naturally occurring intramolecular triplexes play important roles in regulating DNA metabolism and gene function, and are inherently mutagenic and recombinogenic.
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What if humans had triple helix DNA?
Triple Helix DNA Although the function of this form of DNA is not well understood, it has been suggested that triple-stranded DNA helps regulate the expression of certain important genes. Having the extra strand might block transcription, replication, and protein production.
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