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People also ask
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What is the function of the helix in a protein?
The α-helix is the structural element most frequently used for sequence-specific interactions in protein–DNA interfaces. The size of an α-helix matches the width of the DNA major groove, allowing them to fit together tightly while the protein side chains on the helix probe the available base-pair functional groups.
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How does basic helix-loop-helix work?
The bHLH proteins bind to DNA as dimers, using the HLH domain for dimerization and the basic domain for DNA binding. The predominant E-element-binding complex in beta cells consists of a heterodimer formed by a ubiquitous bHLH protein and a cell-type-specific bHLH protein.
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What is the function of the helix-loop-helix?
The basic helix-loop-helix (bHLH) proteins form a large superfamily of transcriptional regulators that are found in organisms from yeast to humans and function in critical developmental processes, including sex determination and the development of the nervous system and muscles.
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How does basic helix-loop-helix work?
The bHLH proteins bind to DNA as dimers, using the HLH domain for dimerization and the basic domain for DNA binding. The predominant E-element-binding complex in beta cells consists of a heterodimer formed by a ubiquitous bHLH protein and a cell-type-specific bHLH protein.
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What does the protein helix-turn-helix do?
Abstract. The helix-turn-helix (HTH) motif is commonly found in proteins that bind DNA, especially transcription factors. In recognizing DNA, the last helix of the HTH motif that is commonly referred to as the recognition helix inserts into the DNA major groove to mediate base-specific DNA recognition.
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What is the function of the helix loop helix proteins?
The basic Helix-Loop-Helix (bHLH) proteins are transcription factors that play important roles during the development of various metazoans including fly, nematode, and vertebrates. They are also involved in human diseases, particularly in cancerogenesis.
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What is the basic helix-loop-helix factor?
Abstract. The basic helix-loop-helix proteins are dimeric transcription factors that are found in almost all eukaryotes. In animals, they are important regulators of embryonic development, particularly in neurogenesis, myogenesis, heart development and hematopoiesis.
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What is the difference between helix loop helix and helix turn helix?
This helix-loop-helix motif is distinct from the helix-turn-helix motif in the homeobox (section 4.2) in that it can form two amphipathic helices, containing all the charged amino acids on one side of the helix, which are separated by a non-helical loop (Murre et al., 1989a).
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