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The Helix Loop Helix Proteins Element Binding Proteins Can Jbc Form
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People also ask
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What is the helix-turn-helix in transcription?
The helix-turn-helix (HTH) domain is a common denominator in basal and specific transcription factors from the three super-kingdoms of life. At its core, the domain comprises of an open tri-helical bundle, which typically binds DNA with the 3rd helix. -
What is the function of the recognition helix?
Abstract. The helix-turn-helix (HTH) motif is commonly found in proteins that bind DNA, especially transcription factors. In recognizing DNA, the last helix of the HTH motif that is commonly referred to as the recognition helix inserts into the DNA major groove to mediate base-specific DNA recognition. -
What is the structure and function of the helix?
helices) is a shape like a corkscrew or spiral staircase. It is a type of smooth space curve with tangent lines at a constant angle to a fixed axis. Helices are important in biology, as the DNA molecule is formed as two intertwined helices, and many proteins have helical substructures, known as alpha helices. -
What are examples of helix-loop-helix?
Examples MyoD. Myf5. Beta2/NeuroD1. Scl, also known as Tal1. proneural bHLH genes like p-CaMKII, and pSer(336)NeuroD. Neurogenins. -
What is the function of the helix-loop-helix motif?
The basic helix-loop-helix (bHLH) proteins form a large superfamily of transcriptional regulators that are found in organisms from yeast to humans and function in critical developmental processes, including sex determination and the development of the nervous system and muscles. -
What are helix turn helix transcription factors?
The helix-turn-helix (HTH) motif is commonly found in proteins that bind DNA, especially transcription factors. In recognizing DNA, the last helix of the HTH motif that is commonly referred to as the recognition helix inserts into the DNA major groove to mediate base-specific DNA recognition. -
What is the function of the helix-turn-helix motif?
The helix-turn-helix (HTH) is a major structural motif capable of binding DNA. Each monomer incorporates two α helices, joined by a short strand of amino acids, that bind to the major groove of DNA. The HTH motif occurs in many proteins that regulate gene expression. -
Which describes the helix-turn-helix motif?
The helix-turn-helix (HTH) is a major structural motif capable of binding DNA. Each monomer incorporates two α helices, joined by a short strand of amino acids, that bind to the major groove of DNA. The HTH motif occurs in many proteins that regulate gene expression. -
What is the basic helix-loop-helix dimer?
The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that bind as dimers to specific DNA target sites and that have been well characterized in nonplant eukaryotes as important regulatory components in diverse biological processes. -
What is the function of the helix loop helix?
The basic Helix-Loop-Helix (bHLH) proteins are transcription factors that play important roles during the development of various metazoans including fly, nematode, and vertebrates. They are also involved in human diseases, particularly in cancerogenesis. -
What is the basic helix-loop-helix DNA-binding?
The bHLH domains of two separate polypeptides can interact to form a dimer that binds DNA as a parallel, left-handed, four-helix bundle. Sequence-specific DNA recognition is mediated primarily by a stretch of basic amino acids that reside near the amino-terminal flank of each dimerized bHLH motif (Figure 1).
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