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Compact Form of SV40 Viral Minichromosome is Resistant to
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What is the structure of the SV40 DNA?
Like most prokaryotic genomes, the SV40 genome is a circular duplex DNA organized in a single replicon. This small viral genome, its association with host histones in nucleosomes, and its dependence on the host cell milieu for replication factors and precursors led to its adoption as a simple and powerful model. -
What is the structure of the SV40 virus?
The shell is constructed of 72 VP1 pentamers, which are tied together by their C-terminal arms. Twelve of the pentamers are surrounded by five other pentamers, and sixty are surrounded by six pentamers [1], [6]. Each pentamer donates five arms to and receives five arms from surrounding pentamers. -
What is the structure of the capsid of SV40?
Its capsid is 45 nm in diameter and is formed by 72 pentameric subunits, each composed of five VP1 major capsid proteins (360 molecules in total). -
What is the structure of the SV40 vector?
SV40 consists of an unenveloped icosahedral virion with a closed circular double-stranded DNA genome of 5.2 kb. The virion adheres to cell surface receptors of MHC class I by the virion glycoprotein VP1. Penetration into the cell is through a caveolin vesicle. -
What are the characteristics of the SV40 virus?
Properties of the Virus. SV40 is in the family Polyomaviridae, which includes JC virus (JCV) and BK virus (BKV). Polyomaviruses are small, nonenveloped, icosahedral DNA viruses. Their genomes consist of a single copy of double-stranded, circular, supercoiled DNA about 5 kb in length. -
What is the role of SV40 virus in carcinogenesis?
The polyomavirus simian virus 40 (SV40) is a known oncogenic DNA virus which induces primary brain and bone cancers, malignant mesothelioma, and lymphomas in laboratory animals.
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