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Compact Form of SV40 Viral Minichromosome is Resistant to

Compact Form of SV40 Viral Minichromosome is Resistant to

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welcome to the session number two of week seven in virology part one this week we're talking about the viral DNA synthesis and in this video we're going to talk about the lessons we have learned about DNA replication using a small DNA virus called sv40 simian virus number 40 now this is a virus with a rather small genome it's a double-stranded DNA circle of about 5,000 kilobase pairs as I should say 5,000 base pairs or five kilo base pairs this DNA has a single origin of replication the origin of replication is the defined specific place in the genome from which DNA replicates initially now our chromosomes have many many origins of replication if they only had one per chromosome it would take many many days to duplicate each chromosome which would not be compatible with with our lives so we have hundreds and hundreds of origins of replication each initiating rounds of DNA replication before the sv40 genome was used as a model for DNA replication we could not study the origins of our DN

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