Zak2 DOC Form

Instructions and help about Zak2 doc

[Music] jack 2 is actually a protein that is linked to several receptors on blood cells what jack 2 does is that it mediates the signal that a blood cell receives in order to differentiate into a more mature cell these cells have receptors that tell them whether they should differentiate into a red cell a white cell or a platelet these receptors are actually coupled to jack 2. what that means is that when the receptor receives a signal that says go ahead and differentiate jack ii sends that signal down to the cell's nucleus or core and tells that cell to divide and differentiate down that line to whatever mature cell that it's signaled to become so the jac2 mutation can be present in mpns polycythemia vera essential thrombocytosis or myelofibrosis the mutated jac2 protein actually leads to excessive signaling that tells the cells to differentiate and divide that excessive signaling that is almost autonomous from the body's signals leads to an excess of these blood cells that defines th