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our abstract is based on a protocol called the my uncle seek study which has been and going on at the University of Michigan since 2011 so so far we've analyzed the data up through 2018 which included a little over 1,000 patients and really the protocol was designed to do next-generation sequencing analysis in a comprehensive way and sequence both the tumor and the normal genome so that we have the opportunity to identify somatic variants that you know we're potentially druggable and could result in you know perhaps offering the patient a clinical trial that was therapeutically relevant but because we were sequencing the match tumor normal we also had this overarching interest in whether or not we would identify you know pathogenic germline variants that were of importance and I think to our surprise although now has also been you know seen by many other studies is that there's a very high incidence of pathogenic germline variants that are seen in patients who o

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