Cholera Toxin Gpo Form

Instructions and help about Cholera Toxin Gpo

cholera a life-threatening disease marked by severe diarrhea is caused by the bacterium vibrio cholerae the diseases typically transmitted by the ingestion of food or water contaminated with human feces in the intestinal tract cholera Vibrio SCID here to the surface of cells the bacterium secretes cholera toxin which has two types of subunits five copies of a B subunit which functions in binding to host cell receptors and one copy of an a subunit which exhibits the toxic activity cholera toxin is structurally similar to many other bacterial toxins that are generally termed a B toxins because it specifically affects the intestines cholera toxin is also called an enteric auxin each of the five B sub units but binds to a glycolipid called ganglia side gm1 on the intestinal cell membranes in this way cholera toxin binds tightly to intestinal epithelial cells the a subunit consists of two domains the a1 domain which contains the toxins activity and the a2 domain which tethers the a subunit