
PPARa Activation Increases Triglyceride Mass and Adipose Jlr Form
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People also ask
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What is the role of triglycerides within adipose tissue?
Triacylglycerol (TAG) in adipose tissue serves as the major energy storage form in higher eukaryotes. Obesity, resulting from excess white adipose tissue, has increased dramatically in recent years resulting in a serious public health problem.
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What increases triglyceride synthesis?
Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid–induced insulin resistance.
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Which of the following hormones stimulates the synthesis of triglycerides?
The hormone that stimulates triglyceride formation in the adipose tissue is. Insulin is produced by the pancreas to regulate glucose metabolism in the body by acting in contrast to glucagon.
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What enzyme activates fatty acids for triacylglycerol biosynthesis?
The reaction is catalyzed by glycerophosphate acyltransferase. Phosphatidic acid is hydrolyzed to 1,2-diacylglycerol by phosphatidic acid phosphohydrolase. A new acyl-CoA molecule transfers another acyl to 1,2-diacylglycerol and triacylglycerol is produced. The enzyme involved is diacylglycerol acyltransferase.
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What is the role of PPAR alpha in lipid metabolism?
Peroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma lipid levels.
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Which hormone stimulates triglyceride synthesis?
Hormones like adrenaline, norepinephrine, and glucagon triggered by fasting, starvation and sympathetic excitement stimulate fat mobilization. Cyclization of adenylate further activates cAMP-dependent protein kinase and increases adipose triglyceride lipase (ATGL) activity.
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What hormone increases triglycerides?
Estrogen also increases triglyceride by promoting synthesis of triglyceride in the liver and secreting this lipid into the circulation as VLDL.
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Which hormone increases the synthesis of triglyceride?
Hormones like adrenaline, norepinephrine, and glucagon triggered by fasting, starvation and sympathetic excitement stimulate fat mobilization. Cyclization of adenylate further activates cAMP-dependent protein kinase and increases adipose triglyceride lipase (ATGL) activity.
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What is an enzyme involved in triacylglycerol biosynthesis?
DGAT1 is the main enzyme for triacylglycerol formation in developing seeds (together with the desaturase FAD2 for provision of linoleate), while DGAT2 is relevant in those plant species with unusual fatty acid compositions.
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